"Line Offline Salaryman" is a comedic anime series that revolves around the daily lives and misadventures of anthropomorphic versions of the LINE messaging app's sticker characters, who work in a corporate office setting. The main characters include Brown, a reserved and hardworking bear; Cony, a cheerful and sometimes overly emotional rabbit; Moon, a laid-back and eccentric boss; James, a narcissistic and self-absorbed horse; and Jessica, a glamorous and confident cat. Each character embodies distinct personality traits that often lead to humorous and relatable workplace scenarios.

The narrative primarily focuses on the interactions and dynamics between these characters as they navigate the challenges of office life, such as meeting deadlines, dealing with office politics, and balancing work with personal life. Brown, often the straight man in the group, frequently finds himself caught in the middle of Cony's emotional outbursts or Moon's unconventional management style. James, with his vanity and self-centered attitude, often creates unnecessary complications, while Jessica adds a touch of sophistication and occasional chaos with her high-maintenance demeanor.

Episodes are structured around episodic, slice-of-life situations that highlight the absurdities and quirks of corporate culture. Themes such as teamwork, ambition, and the pursuit of work-life balance are explored through comedic lenses, often exaggerating real-world office experiences for humorous effect. The series maintains a lighthearted tone, using its characters' exaggerated traits and interactions to deliver relatable and entertaining commentary on modern workplace life.