"Rokudō no Onna-tachi" centers around Tōsuke Rokudō, a high school student cursed with the "Rokudō Evil Eye," an ability that unintentionally attracts dangerous and troublesome women. Despite his desire for a peaceful life, Tōsuke finds himself entangled in chaotic situations as the curse draws women with violent tendencies or dark pasts toward him. The story explores his attempts to navigate these relationships while seeking a way to break the curse.

The narrative begins with Tōsuke transferring to a new school, hoping to escape the chaos caused by the curse. However, his efforts are quickly thwarted when he encounters Ranna Himawari, a delinquent with a fierce temper and a reputation for violence. Ranna becomes inexplicably infatuated with Tōsuke due to the curse, leading to a series of comedic and dramatic confrontations. As the story progresses, other women affected by the curse enter Tōsuke's life, each bringing their own set of challenges and complications.

Among these characters is Chiyo, a yakuza princess with a strong sense of loyalty and a penchant for extreme measures to protect those she cares about. Her involvement with Tōsuke further escalates the tension, as her dangerous lifestyle clashes with his desire for normalcy. Additionally, the series introduces Rei, a former assassin with a tragic past, whose connection to Tōsuke adds layers of emotional depth and moral ambiguity to the story.

The plot balances humor, action, and drama as Tōsuke struggles to manage the chaos caused by the curse. His interactions with the women reveal their individual struggles and motivations, often blurring the lines between antagonist and ally. The series delves into themes of fate, redemption, and the complexities of human relationships, as Tōsuke and the women around him grapple with their intertwined destinies.

Throughout the series, Tōsuke's character evolves as he learns to confront the consequences of the curse and the responsibilities it entails. The women, too, undergo development, with their relationships with Tōsuke serving as catalysts for personal growth and change. The story maintains a dynamic pace, blending comedic moments with intense action sequences and emotional revelations, creating a multifaceted narrative that keeps viewers engaged.