"Gense Shugoshin P-hyoro Ikka" is a supernatural comedy anime that revolves around the P-hyoro family, a group of divine guardians tasked with protecting the balance between the human world and the spirit realm. The family consists of five members, each embodying a different elemental power: fire, water, earth, wind, and lightning. Their mission is to combat malevolent spirits and maintain harmony, but their efforts are often complicated by their own eccentric personalities and chaotic dynamics.

The patriarch, Hyoro, wields fire and serves as the family's leader, though his hot-headed nature frequently leads to comedic mishaps. His wife, Sui, controls water and acts as the voice of reason, often mediating conflicts within the family. Their three children—Chi (earth), Fuu (wind), and Rai (lightning)—each bring their own quirks and challenges. Chi is grounded and responsible but struggles with self-doubt, Fuu is carefree and impulsive, and Rai, the youngest, is mischievous and prone to causing unintentional trouble.

The series unfolds through episodic adventures as the P-hyoro family confronts various supernatural threats, ranging from mischievous spirits to powerful demons. Each episode typically blends action, humor, and light-hearted family drama, with the family members learning to work together despite their differences. The narrative also explores themes of responsibility, unity, and the importance of balancing duty with personal growth.

A recurring antagonist is the demon lord Goma, who seeks to disrupt the balance between worlds for his own gain. Goma's schemes often force the P-hyoro family to confront their weaknesses and grow stronger as a team. While the overarching plot is driven by these conflicts, much of the series' charm lies in its comedic portrayal of the family's everyday struggles, blending supernatural elements with relatable family dynamics. The anime balances its action-packed sequences with moments of humor and heart, creating a lighthearted yet engaging narrative.