"Momoiro Sisters" is a short-form anime series that revolves around the daily lives of two sisters, Aoi and Akane Momoiro, who live together in a small apartment. Aoi, the older sister, is a responsible and hardworking college student who often finds herself dealing with the whims and antics of her younger sister, Akane, a high school student with a more carefree and mischievous personality. The series primarily focuses on their interactions, which range from humorous and lighthearted to moments of genuine sibling bonding.

The narrative is episodic, with each episode presenting a self-contained story that highlights the sisters' contrasting personalities and how they navigate everyday situations. Aoi is often portrayed as the more serious and pragmatic of the two, frequently taking on the role of caretaker for Akane, who tends to be more impulsive and playful. Despite their differences, the sisters share a close and affectionate relationship, which is a central theme throughout the series.

The plotlines are simple and slice-of-life in nature, often involving mundane activities such as cooking, shopping, or dealing with school and work responsibilities. These everyday scenarios are infused with humor, often stemming from Akane's antics or Aoi's exasperated reactions. The series also occasionally touches on themes of family, responsibility, and the challenges of balancing personal aspirations with the demands of daily life.

Supporting characters, such as friends and acquaintances, occasionally appear to add variety to the stories, but the focus remains firmly on the dynamic between Aoi and Akane. The series does not delve deeply into dramatic or complex plotlines, instead opting for a lighthearted and relatable portrayal of sibling relationships. The simplicity of the narrative, combined with its short episode format, makes it an easy and enjoyable watch for those seeking a casual, slice-of-life experience.