"Super Milk-chan" is a surreal and comedic anime series that revolves around the eccentric and chaotic life of Milk-chan, a foul-mouthed, anthropomorphic baby with a penchant for causing trouble. The narrative unfolds in a bizarre, satirical world where absurdity reigns, blending dark humor with slapstick comedy. Milk-chan lives with her long-suffering caretaker, Tetsuko, a hardworking office lady who struggles to manage Milk-chan's antics while navigating her own mundane life. The dynamic between the two characters forms the core of the series, with Milk-chan often manipulating or tormenting Tetsuko for her own amusement.

The series is episodic, with each episode presenting self-contained stories that highlight Milk-chan's unpredictable behavior and the strange world she inhabits. Supporting characters include Hanage, a sentient, talking nose hair who serves as Milk-chan's sidekick, and various other oddball figures who populate the show's universe. The humor often derives from exaggerated situations, absurd dialogue, and the stark contrast between Milk-chan's infantile appearance and her crude, adult-like personality.

Themes of existentialism and societal critique are woven into the narrative, though they are presented through a lens of absurdity and satire. The series frequently breaks the fourth wall, with characters acknowledging their roles in a fictional story, adding to the meta-humor. Despite its comedic tone, "Super Milk-chan" occasionally delves into darker, more introspective moments, reflecting on themes of loneliness, identity, and the human condition.

The animation style is distinctive, characterized by its minimalist design and exaggerated expressions, which complement the show's offbeat tone. The series does not follow a traditional plot structure but instead relies on its quirky characters and surreal scenarios to drive the narrative forward. "Super Milk-chan" stands out for its unconventional approach to storytelling, blending humor, absurdity, and occasional moments of poignancy to create a unique viewing experience.