"Lupin the 3rd: From Siberia with Love" is a direct-to-video anime special that centers on the exploits of the master thief Arsène Lupin III and his team. The story begins with Lupin and his partner Jigen stealing a valuable artifact, the "Eternal Ice," from a heavily guarded facility in Siberia. The artifact is said to contain a hidden treasure map leading to a legendary fortune buried in the frozen tundra. However, their heist attracts the attention of a powerful Russian crime syndicate led by the ruthless Colonel Zarkov, who is determined to reclaim the artifact for his own purposes.

As Lupin and Jigen evade Zarkov's forces, they reunite with their allies, the sharpshooter Goemon and the enigmatic Fujiko Mine. Together, the group deciphers the clues hidden within the Eternal Ice, which point to a secret location deep within Siberia. The journey takes them through treacherous terrain, where they face not only Zarkov's relentless pursuit but also the harsh and unforgiving environment of the Siberian wilderness. Along the way, Lupin's cunning and resourcefulness are put to the test as he devises elaborate schemes to outwit his enemies.

The narrative also explores the dynamics between the characters, particularly Lupin's complicated relationship with Fujiko, whose loyalties remain ambiguous. Inspector Zenigata, Lupin's perennial nemesis, also makes an appearance, adding another layer of tension as he attempts to capture Lupin while navigating the chaos caused by Zarkov's syndicate. The story builds toward a climactic confrontation in the frozen wasteland, where the true nature of the treasure is revealed, and Lupin must decide whether the pursuit of wealth is worth the risks involved.

The special maintains the signature blend of action, humor, and intrigue that defines the Lupin the 3rd franchise, while introducing new challenges and adversaries that push the characters to their limits. The plot is driven by a series of heists, chases, and double-crosses, culminating in a resolution that underscores Lupin's enduring appeal as a charismatic and unpredictable antihero.