"Chimimo" is a supernatural comedy anime that centers around the daily lives of the Hozuki siblings and their encounters with mischievous spirits known as Chimimo. The story begins when middle schooler Mei Hozuki and her younger brother, Jirou, accidentally summon a group of Chimimo while attempting to perform a ritual to improve their luck. These Chimimo, led by the gluttonous and lazy Hazuki, are small, otherworldly creatures with distinct personalities and abilities. Despite their initial intentions to cause chaos, the Chimimo end up living with the Hozuki family, leading to a series of humorous and heartwarming situations.

The Chimimo include Hazuki, who is obsessed with food and often causes trouble; Satsuki, a serious and responsible leader figure; Minazuki, a shy and timid spirit; and Fumizuki, a cheerful and energetic character. Each episode explores the interactions between the Hozuki siblings and the Chimimo, blending slapstick comedy with moments of familial bonding. The series also introduces other supernatural elements, such as rival spirits and mysterious entities, which add depth to the episodic narrative.

Throughout the series, the Hozuki siblings navigate their everyday lives while dealing with the unpredictable antics of the Chimimo. Mei, a diligent and responsible student, often finds herself at odds with the Chimimo's chaotic behavior, while Jirou, a curious and imaginative child, embraces their presence. The dynamic between the siblings and the Chimimo evolves as they learn to coexist, with the spirits occasionally helping the family in unexpected ways. The anime balances lighthearted humor with subtle themes of family, responsibility, and the importance of understanding others, making it an engaging watch for audiences of all ages.