"Hugtto! Precure Futari wa Precure All Stars Memories" is a crossover film that brings together characters from the "Hugtto! Precure" series and the broader "Pretty Cure" franchise. The narrative centers on the Hugtto! Precure team—Hana Nono (Cure Yell), Saaya Yakushiji (Cure Ange), Homare Kagayaki (Cure Étoile), and Emiru Aisaki (Cure Macherie)—as they encounter a mysterious girl named Papple. Papple is searching for her lost memories and seeks the help of the Precure teams to recover them. The story unfolds as the Hugtto! team joins forces with Precure heroes from previous series to protect Papple and uncover the truth behind her forgotten past.

The plot takes a dramatic turn when Papple’s memories are revealed to be tied to a powerful artifact known as the "Memorial Stone," which holds the collective memories of all Precure teams. A new antagonist, Dr. Traum, emerges, aiming to exploit the Memorial Stone’s power to erase the memories of all Precure warriors, thereby undoing their heroic deeds and the bonds they’ve formed. The Precure teams must unite to stop Dr. Traum and his minions, who seek to manipulate Papple’s connection to the stone for their own nefarious purposes.

Throughout the film, the narrative emphasizes themes of unity, friendship, and the enduring power of memories. The Hugtto! team, alongside their predecessors, demonstrates the strength of their collective resolve as they face increasingly challenging battles. The climax features a large-scale confrontation where all Precure teams combine their powers to protect Papple and restore the Memorial Stone, ensuring that the memories and bonds of the Precure legacy remain intact. The film concludes with Papple regaining her memories and the Precure teams reaffirming their commitment to protecting hope and love across the universe.