"Ai-Mai-Mi Mōsō Catastrophe" is a surreal comedy anime and manga series that blends slice-of-life elements with absurdist humor and fantastical twists. The story revolves around three high school girls—Ai Ebihara, Mai Kawakami, and Mi Ohara—who are members of their school's manga club. Their daily lives are anything but ordinary, as they frequently find themselves entangled in bizarre, dreamlike scenarios that defy logic and reality. These situations often involve exaggerated, over-the-top events, such as battling supernatural entities, navigating alternate dimensions, or confronting their own exaggerated fears and insecurities.

The narrative structure is episodic, with each chapter or episode presenting a self-contained story that explores the girls' interactions and reactions to the strange world around them. Despite the chaotic and unpredictable nature of their adventures, the core of the series remains the dynamic between the three protagonists. Ai is the most level-headed and pragmatic of the group, often serving as the voice of reason. Mai is energetic and impulsive, frequently driving the group into absurd situations, while Mi is shy and reserved, often providing a contrast to the others' antics.

The series frequently breaks the fourth wall, with characters acknowledging their roles in a fictional narrative and even commenting on the absurdity of their circumstances. This meta-humor is a recurring theme, adding an additional layer of comedy to the already chaotic plotlines. The manga club setting serves as a backdrop for many of these adventures, with the girls often attempting to create manga or discuss storytelling tropes, only to be sidetracked by increasingly surreal events.

While the series lacks a continuous overarching plot, its charm lies in its ability to balance humor, character dynamics, and unexpected twists. The absurdity of the situations is juxtaposed with moments of genuine camaraderie and growth among the characters, creating a unique blend of comedy and heart. The series appeals to fans of surreal humor and those who enjoy stories that challenge conventional narrative structures.