"Shōjo Fight" centers on Neri Oono, a high school girl who becomes involved in the world of underground fighting after a chance encounter with a mysterious fighter named Ran. Neri, initially a reserved and unassuming student, discovers her latent talent for combat when she is drawn into Ran's world. The series explores Neri's journey as she trains, competes, and navigates the challenges of balancing her ordinary school life with her newfound identity as a fighter.

The underground fighting scene is depicted as a gritty, high-stakes environment where fighters from diverse backgrounds compete for recognition, survival, and personal goals. Neri's progression is marked by her encounters with rival fighters, each with their own motivations and backstories. These interactions reveal the complexities of the fighting world, including themes of loyalty, betrayal, and self-discovery. Ran serves as both a mentor and a rival, pushing Neri to confront her limits while grappling with her own past and ambitions.

As Neri gains experience, she faces increasingly formidable opponents, leading to intense and strategic battles that test her physical and mental resilience. The series delves into the psychological toll of competition, as well as the camaraderie and rivalries that develop among the fighters. Neri's relationships with her peers, both in and out of the fighting arena, play a significant role in her growth, highlighting the interplay between personal connections and individual ambition.

The narrative also examines the societal pressures and expectations placed on young women, using the fighting arena as a metaphor for broader struggles. Neri's journey is not just about mastering combat but also about asserting her identity and finding her place in a world that often marginalizes her. The series balances action-packed fight sequences with moments of introspection, creating a multifaceted portrayal of its protagonist and the world she inhabits.