"Sex Pistols" is an anime series adapted from the manga by Ishinomori Shotaro. The story is set in a world where humans coexist with anthropomorphic animals, known as Beastmen, who possess human-like intelligence and emotions. The narrative centers on Norio, a young man who becomes entangled in a dangerous conspiracy after encountering a mysterious Beastman named Saruwatari. Saruwatari is a skilled assassin tasked with eliminating Norio, but their fates become intertwined when Norio discovers he possesses a unique genetic trait that makes him a target for various factions.

The plot unfolds as Norio and Saruwatari form an uneasy alliance to survive and uncover the truth behind the genetic experiments that have shaped their world. These experiments, conducted by a shadowy organization, aim to create a superior race by blending human and Beastman DNA. Norio’s genetic makeup makes him a key figure in this scheme, drawing the attention of both the organization and rival groups seeking to exploit or destroy him.

Throughout the series, the relationship between Norio and Saruwatari evolves from one of mutual distrust to a complex partnership. Saruwatari’s loyalty is tested as he grapples with his role as an assassin and his growing connection to Norio. The narrative explores themes of identity, survival, and the ethical implications of genetic manipulation, set against a backdrop of action and intrigue.

The supporting cast includes other Beastmen and humans who play pivotal roles in the unfolding conflict. Characters such as the enigmatic scientist Dr. Tachibana and the ruthless mercenary group led by Kikunojo add layers of complexity to the story, as their motivations and allegiances shift in response to the escalating tension. The series balances its darker themes with moments of humor and camaraderie, particularly in the interactions between Norio and Saruwatari.

As the story progresses, the stakes rise, culminating in a confrontation that forces Norio and Saruwatari to confront their pasts and the consequences of the experiments that have shaped their lives. The series concludes with a resolution that ties together the central conflicts while leaving room for reflection on the broader implications of the world it portrays.