"Ashiaraiyashiki no Jūnin-tachi" is a surreal and episodic anime series that revolves around the peculiar inhabitants of a rundown apartment complex known as Ashiaraiyashiki. The building is home to a diverse group of eccentric characters, each with their own bizarre quirks and supernatural traits. The central figure is the landlord, a mysterious and imposing man who enforces strict rules and demands rent payments in unconventional ways, often involving strange and humorous tasks. His interactions with the tenants drive much of the series' comedic and absurd tone.

The tenants include a wide array of individuals, such as a man with a giant foot for a head, a woman who can transform into a cat, and a ghostly child who haunts the hallways. Each episode typically focuses on a specific tenant or a particular incident within the apartment, blending comedy, horror, and fantasy elements. The stories often explore themes of isolation, identity, and the absurdity of human behavior, all while maintaining a lighthearted and whimsical atmosphere.

The narrative structure is non-linear, with episodes functioning as self-contained vignettes that gradually reveal more about the characters and the building's strange history. Despite the surreal and often chaotic events, there is an underlying sense of camaraderie among the tenants, who navigate their peculiar lives together. The series balances its bizarre humor with moments of poignancy, creating a unique and memorable viewing experience.