"Soreyuke! Gedou Otometai" is a comedic anime series that revolves around a group of high school girls who form a villainous organization called Gedou Otometai, aiming to conquer the world. The group consists of five members: the leader, Aiko, who is determined but often clumsy; the stoic and serious Miko; the energetic and mischievous Riko; the shy and reserved Yuko; and the eccentric and unpredictable Saki. Despite their grandiose ambitions, their plans are consistently undermined by their own incompetence and the interference of a rival hero group, the Justice Rangers.

The narrative unfolds in a lighthearted and episodic manner, with each episode featuring the Gedou Otometai attempting various schemes to achieve world domination. These schemes often involve creating bizarre inventions, staging elaborate traps, or engaging in absurd battles with the Justice Rangers. However, their efforts are frequently met with failure, either due to their lack of coordination, the Justice Rangers' intervention, or their own comedic missteps. The series balances slapstick humor with moments of camaraderie among the group, highlighting their quirky personalities and the absurdity of their mission.

Throughout the series, the dynamic between the Gedou Otometai and the Justice Rangers evolves, with both groups occasionally finding common ground or engaging in unexpected alliances. Despite their rivalry, the interactions between the characters often reveal a sense of mutual respect and even friendship. The anime maintains a consistent tone of over-the-top humor and satire, poking fun at traditional hero-villain tropes while exploring the absurdity of the characters' ambitions and the world they inhabit. The story concludes with the Gedou Otometai continuing their quest for world domination, embracing their failures and persisting in their comically flawed endeavors.