"Sukisho" centers around Sora Hashiba, a high school student who loses his memories after a traumatic fall from a school building. Upon waking, Sora discovers he shares his body with another personality named Yoru, a mischievous and carefree individual who claims to have existed within him for years. The two personalities struggle to coexist, often clashing over control of their shared body. As Sora attempts to regain his memories, he reconnects with his childhood friend, Sunao Fujimori, and other classmates, including the enigmatic twins, Matsuri and Shinichiro Nanami.

The narrative delves into Sora’s past, revealing a complex web of relationships and secrets tied to a mysterious incident from his childhood. It becomes apparent that Yoru’s existence is linked to this event, and the two personalities must confront their shared history to resolve their internal conflict. The story explores themes of identity, trauma, and the bonds of friendship, as Sora and Yoru navigate their dual existence while uncovering the truth behind their connection.

Key characters include Sunao, who harbors deep feelings for Sora and plays a pivotal role in helping him piece together his memories. The Nanami twins add layers of intrigue, with Matsuri’s cheerful demeanor contrasting Shinichiro’s aloof and calculating nature. Their involvement in Sora’s past gradually comes to light, revealing their own motivations and connections to the central mystery. The series balances moments of lighthearted humor with darker, emotional undertones, creating a narrative that intertwines personal growth with the resolution of long-buried secrets.