"Sore ga Seiyū!" is a slice-of-life anime that delves into the professional and personal lives of voice actors in Japan. The story centers on Futaba Ichinose, a rookie voice actress who joins a talent agency and begins her journey in the competitive world of voice acting. Alongside her are Ichigo Moesaki, a cheerful and experienced voice actress who becomes Futaba's mentor, and Rin Kohana, a shy and reserved newcomer who struggles with confidence. The series explores their daily challenges, from auditions and recording sessions to balancing work with personal life.

The narrative highlights the intricacies of the voice acting industry, showcasing the dedication and perseverance required to succeed. Futaba faces numerous obstacles, including self-doubt, rejection, and the pressure to improve her skills. Ichigo provides guidance and support, often sharing her own experiences to help Futaba navigate the industry. Rin, on the other hand, grapples with her introverted nature and learns to overcome her fears to pursue her passion.

The series also introduces other characters within the agency, such as veteran voice actors and industry professionals, who offer insights into the broader landscape of voice acting. Through their interactions, the anime portrays the camaraderie and competition that coexist in the field. Episodes often focus on specific projects, such as dubbing foreign films, recording for anime, or participating in live events, providing a behind-the-scenes look at the creative process.

As the story progresses, Futaba, Ichigo, and Rin grow both professionally and personally. They face setbacks and celebrate small victories, learning valuable lessons about resilience, teamwork, and self-expression. The anime balances lighthearted moments with more serious themes, offering a realistic portrayal of the challenges and rewards of pursuing a career in voice acting. The narrative emphasizes the importance of passion and perseverance, making it an engaging and informative exploration of the industry.