"Dirty Pair" is a science fiction anime series set in the 22nd century, where humanity has colonized numerous planets across the galaxy. The story centers on Kei and Yuri, two highly skilled but chaotic trouble consultants working for the World Welfare Works Association (3WA), an organization tasked with solving problems across the universe. Known as the "Lovely Angels," their official designation is Code Name: Dirty Pair. Despite their competence, their missions often result in collateral damage, earning them a reputation for leaving destruction in their wake.

Kei is impulsive, brash, and confident, often charging headfirst into situations with little regard for consequences. Yuri, by contrast, is more analytical and level-headed, frequently attempting to temper Kei's recklessness. Their contrasting personalities create a dynamic partnership that drives both the humor and tension of the series. Together, they tackle a variety of assignments, ranging from corporate espionage and hostage situations to thwarting criminal organizations and uncovering conspiracies.

The episodic structure of the series allows for a wide range of adventures, each showcasing the duo's problem-solving skills and their tendency to escalate situations unintentionally. Despite their destructive track record, they consistently achieve their objectives, often through a combination of ingenuity, combat prowess, and sheer luck. The series balances action, comedy, and occasional moments of introspection, with Kei and Yuri occasionally reflecting on the moral implications of their work and the consequences of their actions.

Supporting characters include their 3WA superiors, who often express exasperation at the pair's methods, as well as recurring allies and adversaries who add depth to the narrative. The series also explores the futuristic setting, featuring advanced technology, interstellar travel, and diverse alien cultures, which serve as a backdrop for the duo's exploits. While primarily lighthearted, "Dirty Pair" occasionally delves into darker themes, such as corruption, betrayal, and the ethical dilemmas of intervention in interplanetary conflicts.

The anime's blend of action, humor, and science fiction elements has made it a notable entry in the genre, with Kei and Yuri's partnership standing out as a defining aspect of the series. Their adventures highlight both their competence as agents and their chaotic tendencies, creating a unique balance that has resonated with audiences.