"Unhappy," also known as "Anne Happy" or "Annehappy♪," is a slice-of-life comedy anime set in Tennomifune Academy, a school where students are sorted into classes based on their misfortunes. The story centers on a group of girls in Class 1-7, labeled the "Happiness Class," who are tasked with overcoming their perpetual bad luck. The series explores their daily lives as they navigate their unique challenges while striving to find happiness.

The protagonist, Hanakoizumi An, is a cheerful and optimistic girl cursed with extreme misfortune. Despite her constant accidents and failures, she maintains a positive outlook. Her classmates include Hibari Hagyu, a wealthy heiress with a frail constitution that leaves her perpetually ill; Botan Kumegawa, a girl with poor eyesight and a tendency to attract wild animals; Ruri Hibarigaoka, a quiet and stoic girl who is constantly followed by bad weather; and Ren Ekoda, a teacher who is equally unlucky and serves as their homeroom instructor. Together, they form a close-knit group, supporting each other through their shared struggles.

The narrative unfolds through episodic adventures, often involving the girls participating in school activities or attempting to improve their situations. These activities range from mundane tasks like gardening to more absurd scenarios, such as surviving a haunted house or competing in a school festival. The humor arises from the characters' exaggerated misfortunes and their resilience in the face of adversity. While the tone is primarily lighthearted, the series occasionally touches on themes of friendship, perseverance, and finding joy in small victories.

The interactions between the characters drive much of the story, with their contrasting personalities creating a dynamic and entertaining group dynamic. An's unwavering optimism contrasts with Hibari's refined but fragile demeanor, Botan's clumsiness, and Ruri's quiet resignation. Ren, despite being an adult, often finds herself caught up in the same misfortunes as her students, adding to the comedic elements.

"Unhappy" balances its comedic premise with moments of genuine warmth, emphasizing the importance of camaraderie and resilience. The series does not delve deeply into dramatic or emotional arcs but instead maintains a consistent focus on the characters' efforts to overcome their bad luck and find happiness in their everyday lives. Through its episodic structure and humorous approach, the anime offers a light-hearted exploration of misfortune and the ways in which people can find joy despite their circumstances.