"Gakuen Handsome" is a short-form anime series that parodies the conventions of the boys' love (BL) and romance genres, particularly focusing on the tropes found in otome games and visual novels. The story is set at Baramon High School, a prestigious all-boys academy, where the protagonist, a transfer student, becomes the center of attention among a group of strikingly handsome male classmates. Each of these characters embodies exaggerated archetypes commonly seen in romantic narratives, such as the mysterious transfer student, the childhood friend, the delinquent, the student council president, and the aloof genius.

The protagonist, whose name is never revealed, navigates a series of absurd and comedic interactions with these characters, often leading to over-the-top romantic or dramatic situations. The narrative frequently employs surreal humor, with characters' chins becoming impossibly sharp or their faces contorting in exaggerated expressions. The plot is episodic, with each episode focusing on a different character or scenario, often culminating in a humorous or nonsensical resolution. Despite the romantic undertones, the series leans heavily into parody, subverting expectations by highlighting the absurdity of its own genre conventions.

The main characters include the protagonist, who remains a blank slate to allow for audience projection, and the various love interests: Maeda, the childhood friend with a perpetually sharp chin; Kajima, the delinquent with a penchant for dramatic entrances; Okosan, the eccentric and unpredictable student council president; and Hoshino, the aloof and mysterious genius. Each character is defined by their exaggerated traits and interactions, which are played for comedic effect rather than genuine emotional depth.

The series is notable for its minimalist animation style, which further emphasizes its satirical approach. The humor derives from the contrast between the characters' overly serious demeanors and the ridiculousness of their situations. While the narrative does not follow a traditional plot structure, it consistently maintains a tone of self-aware parody, poking fun at the tropes and clichés of the genres it imitates. The brevity of each episode, combined with the rapid pacing, ensures that the humor remains sharp and focused, making "Gakuen Handsome" a distinctive entry in the realm of parody anime.