"How Clumsy You Are, Miss Ueno" is a short-form comedy anime centered around the eccentric and over-the-top antics of Ueno, a brilliant but socially awkward high school student who is a member of her school's science club. Ueno is secretly in love with her classmate, Tanaka, a kind but oblivious boy who remains unaware of her feelings. To win his affection, Ueno devises a series of increasingly absurd and elaborate inventions, often using her scientific expertise to create gadgets that she believes will make Tanaka fall for her. However, her plans frequently backfire due to her lack of social skills and the impracticality of her inventions.

The series is structured as a series of comedic vignettes, with each episode focusing on Ueno's latest scheme to impress Tanaka. Her inventions range from bizarre to outright dangerous, often causing unintended chaos or embarrassment. Despite her intelligence, Ueno's emotional immaturity and single-minded obsession with Tanaka lead to humorous misunderstandings and awkward situations. Tanaka, on the other hand, remains largely oblivious to Ueno's feelings, treating her with polite indifference and occasionally expressing mild confusion at her behavior.

Another key character is Yamashita, Ueno's long-suffering friend and fellow science club member. Yamashita often finds herself caught in the middle of Ueno's schemes, serving as a voice of reason and occasionally trying to rein in Ueno's more extreme ideas. However, her efforts are usually futile, as Ueno's determination and lack of self-awareness make her difficult to dissuade. The dynamic between Ueno, Tanaka, and Yamashita forms the core of the series, with their interactions driving much of the humor.

The anime's humor is rooted in its exaggerated situations, slapstick comedy, and Ueno's relentless pursuit of Tanaka despite her repeated failures. The tone is lighthearted and absurd, with a focus on quick, episodic gags rather than a continuous narrative. While the series does not delve deeply into character development or emotional depth, it effectively uses its premise to deliver consistent comedic moments, making it a straightforward and entertaining watch for fans of short-form comedy.