"This Art Club Has a Problem!" centers on the daily lives of the members of an art club at a middle school, blending comedy and lighthearted drama. The club is led by Uchimaki Subaru, a talented but eccentric artist obsessed with drawing the perfect "2D wife," and Usami Mizuki, a cheerful and energetic girl who harbors feelings for Subaru but struggles to express them. The club also includes Colette, a transfer student with a quirky personality and a penchant for creating bizarre art, and Imari, the club president, who often acts as the voice of reason amidst the chaos.

The narrative unfolds through episodic vignettes, focusing on the interactions and misadventures of the club members. Subaru's single-minded dedication to his 2D creations often leads to humorous misunderstandings, particularly with Usami, who frequently tries to steer his attention toward the real world. Usami's attempts to win Subaru's affection are met with his obliviousness, creating a recurring comedic dynamic. Colette's eccentricities and Imari's attempts to maintain order add further layers of humor and unpredictability to the club's activities.

The series explores themes of creativity, friendship, and the challenges of adolescence, often using the art club as a backdrop for character development. Subaru's growth is marked by subtle shifts in his perspective, as he begins to appreciate the value of real-world relationships alongside his artistic pursuits. Usami's journey revolves around her efforts to balance her feelings for Subaru with her desire to support his passions. Colette's unique worldview and Imari's pragmatic approach provide contrasting perspectives, enriching the group dynamic.

The episodic structure allows for a variety of scenarios, from school festivals and art competitions to more mundane club activities, all infused with humor and charm. The series maintains a light tone, avoiding heavy drama while still addressing relatable teenage experiences. The characters' interactions and growth are central to the narrative, making "This Art Club Has a Problem!" a character-driven comedy with a focus on the joys and challenges of artistic expression and interpersonal relationships.