"Pretty Boy Detective Club" is a 12-episode anime series based on the light novel series by NISIOISIN. The story centers on Mayumi Dojima, a second-year middle school student who becomes entangled with a group of five exceptionally handsome and eccentric boys known as the Pretty Boy Detective Club. Each member of the club possesses unique talents and personalities, and they solve mysteries that range from the mundane to the fantastical. The club operates under the motto of pursuing "beauty, romance, and justice," often blurring the lines between reality and whimsy.

Mayumi's involvement with the club begins when she seeks their help to find a star she saw in the night sky ten years ago, a memory that has haunted her ever since. The club's leader, Manabu Sotoin, a charismatic and enigmatic figure, takes an immediate interest in her case. The other members include Nagahiro Sakiguchi, a sharp-tongued and analytical boy; Hyota Ashikaga, a quiet and observant individual with a knack for photography; Michiru Fukuroi, a cheerful and energetic boy with a talent for disguise; and Sosaku Yubiwa, a refined and artistic boy who often provides creative solutions to their cases. Together, they embark on a series of investigations that often intertwine with themes of beauty, illusion, and the supernatural.

The narrative unfolds through episodic mysteries, each highlighting the unique skills of the club members while gradually revealing deeper connections between the cases and the characters' personal histories. The star Mayumi seeks becomes a recurring motif, symbolizing her longing for meaning and connection. As the series progresses, the club uncovers secrets about their school, the town, and even their own identities, often encountering larger-than-life antagonists and surreal scenarios. The tone of the series balances lighthearted humor with moments of introspection, blending the whimsical with the profound.

The anime's structure allows for both standalone episodes and an overarching narrative, culminating in a resolution that ties together the central mystery of Mayumi's star and the club's purpose. The characters' interactions and growth are central to the story, with each member contributing to the group dynamic in distinct ways. The series explores themes of beauty, perception, and the pursuit of ideals, often challenging the characters to confront their own beliefs and desires. Through its blend of mystery, fantasy, and character-driven storytelling, "Pretty Boy Detective Club" offers a unique and engaging narrative that appeals to fans of both detective fiction and surrealist storytelling.