Nico Robin journeys with the Straw Hat Pirates to Drum Island seeking medical aid for the ill Nami. Alongside Luffy, Sanji, and Usopp, she helps transport Nami up the mountain towards Doctor Kureha. An avalanche strikes during the climb, burying Usopp under snow. Robin employs her Hana Hana no Mi Devil Fruit power, sprouting multiple arms from surrounding surfaces to dig both herself and Usopp free, then slaps Usopp awake.

At Drum Castle, Robin engages in the conflict against Wapol and his brother, Musshuru. When Musshuru uses his Devil Fruit ability to unleash poisonous spores, poisoning Luffy during their fight, Robin swiftly administers an antidote after Usopp attacks Musshuru. This counteracts the poison, enabling Luffy to resume combat using his Gear Second ability. Following the defeat of Wapol and Musshuru, Robin aids Nami in negotiating with Doctor Kureha for Tony Tony Chopper to join the Straw Hat crew. She provides Kureha with the antidote to Musshuru's poisonous spores as part of this exchange.

Her presence during these Drum Island events represents a narrative alteration, as both she and Franky participate in a storyline chronologically preceding their recruitment in the main series. Her actions during the avalanche and providing medical assistance substitute for roles originally filled by other characters in the source material.