"Me & Roboco" is a comedic anime series centered around the daily life of Bondo, a middle school student who dreams of owning a high-end robot maid like those featured in his favorite manga, "Jajako." Bondo's mundane life takes a turn when his mother orders a robot maid named Roboco from a mysterious company. Unlike the sleek, efficient robots Bondo admires, Roboco is a clumsy, eccentric, and overly powerful machine with a penchant for causing chaos. Despite her flaws, Roboco is fiercely loyal and determined to assist Bondo, often leading to absurd and humorous situations.

The series explores the dynamic between Bondo, Roboco, and their classmates, including Bondo's best friend, Gachi Gorilla, a muscular and dim-witted boy, and Motsuo, a quiet and studious classmate who often finds himself caught in Roboco's antics. Roboco's over-the-top personality and unpredictable behavior frequently disrupt Bondo's attempts at a normal life, whether it's at school, home, or during his leisure time. Her exaggerated strength and lack of common sense often result in comedic mishaps, but her genuine desire to help Bondo and her friends adds a layer of warmth to the narrative.

Throughout the series, Roboco's origins and the true nature of the company that created her remain shrouded in mystery, occasionally hinting at a larger, unexplored backstory. However, the focus remains on the episodic, slice-of-life humor, with each episode presenting new challenges and absurd scenarios. The interactions between the characters, particularly Roboco's attempts to fit into human society, drive the comedic tone of the series. The show balances slapstick humor with moments of camaraderie, highlighting the quirky yet endearing relationships between Bondo, Roboco, and their friends.