"Punch Line" is a 12-episode anime series that blends elements of science fiction, comedy, and mystery. The story centers on Yuta Iridatsu, a high school student who becomes separated from his body after a bus hijacking incident. His soul ends up inhabiting a shared boarding house called Korai House, where he encounters a group of eccentric residents: Mikatan Narugino, a cheerful and athletic girl; Ito Hikiotani, a reclusive otaku; Meika Daihatsu, a genius inventor; and Rabura Chichibu, a mysterious cat spirit. Yuta discovers that his newfound ghostly state grants him supernatural abilities, but these powers come with a significant catch: if he sees a girl’s underwear twice in a row, a catastrophic event will occur, potentially leading to the destruction of the world.

As Yuta navigates his peculiar predicament, he uncovers a larger conspiracy involving a terrorist organization called Strange Juice, which seeks to harness the power of a mysterious substance called "Punch Line" to trigger a global catastrophe. The narrative unfolds through a mix of comedic and dramatic moments, with Yuta and the residents of Korai House working together to prevent the impending disaster. The story incorporates time loops, alternate realities, and intricate connections between characters, gradually revealing the true nature of Yuta’s separation from his body and the significance of the Punch Line substance.

The series balances its lighthearted humor with a complex, layered plot that explores themes of friendship, sacrifice, and the consequences of one’s actions. Key revelations about the characters’ pasts and motivations are interwoven with the overarching mystery, culminating in a resolution that ties together the various narrative threads. "Punch Line" stands out for its unique premise, blending absurdity with a tightly constructed storyline that rewards attentive viewers with its intricate details and unexpected twists.