"Shirobako" is a 24-episode anime series that delves into the intricacies of the anime production industry, offering a behind-the-scenes look at the challenges and triumphs faced by those involved in creating animated works. The story centers on five friends—Aoi Miyamori, Ema Yasuhara, Shizuka Sakaki, Misa Toudou, and Midori Imai—who aspire to work in the anime industry after creating an animated short for their high school cultural festival. Each character pursues a different role within the industry, and the narrative follows their professional and personal growth as they navigate the demanding world of anime production.

Aoi Miyamori, the protagonist, works as a production assistant at Musashino Animation, a fictional anime studio. Her role involves coordinating between various departments, managing schedules, and ensuring deadlines are met, often under intense pressure. Ema Yasuhara, an animator, struggles with the technical and creative demands of her job, striving to improve her skills while meeting tight deadlines. Shizuka Sakaki, an aspiring voice actress, faces the competitive nature of the industry, enduring numerous auditions and rejections in pursuit of her dream. Misa Toudou, a 3D CGI artist, grapples with the challenges of integrating 3D animation into traditional 2D projects, while Midori Imai, a writer and storyboard enthusiast, seeks to break into the industry by contributing creative ideas and scripts.

The series provides a detailed portrayal of the anime production process, from initial concept development and scriptwriting to animation, voice recording, and post-production. It highlights the collaborative nature of the industry, emphasizing the importance of teamwork and communication. Key supporting characters include production managers, directors, animators, and voice actors, each contributing to the creation of the anime within the story. The narrative also explores the personal struggles and aspirations of these characters, offering a humanizing perspective on the often-glamorized industry.

Throughout the series, the characters work on two major projects: "Exodus!," a fantasy action anime, and "Third Aerial Girls Squad," a military-themed series. These projects serve as a backdrop for exploring the challenges of balancing creative vision with practical constraints, such as budget limitations, tight schedules, and technical difficulties. The series also touches on broader themes, such as the impact of corporate decisions on creative processes and the evolving nature of the anime industry in response to technological advancements and changing audience preferences.

"Shirobako" is notable for its realistic depiction of the anime production process, offering viewers an informative and engaging look at the industry. The series combines workplace drama with moments of humor and camaraderie, creating a balanced narrative that appeals to both anime enthusiasts and those interested in the creative industries. By focusing on the experiences of its diverse cast of characters, "Shirobako" provides a comprehensive and insightful exploration of the challenges and rewards of working in anime production.