"High School! Kimengumi" is a comedic anime series set in the fictional Kimengumi High School, where the story revolves around the misadventures of a group of eccentric students. The central characters are five boys: Ryūnosuke Fujinami, a laid-back and carefree individual; Hikaru Hiyama, a self-proclaimed ladies' man; Shinobu Miyahara, a shy and introverted boy; Kentarō Inenaga, a hot-headed and impulsive student; and Shōgo Kadokura, a quiet and mysterious figure. Together, they form an unlikely group that navigates the absurdities of high school life.

The narrative is episodic, with each episode presenting a new comedic scenario or challenge. The students often find themselves in ridiculous situations, ranging from attempting to impress girls to dealing with bizarre school events. The humor is derived from their exaggerated personalities and the over-the-top reactions to mundane high school problems. The series also features a colorful cast of supporting characters, including teachers and classmates, who contribute to the chaotic atmosphere of the school.

One recurring theme is the group's attempts to gain popularity or achieve personal goals, which frequently backfire due to their incompetence or bad luck. For instance, they might try to organize a school festival, only to have it spiral into chaos, or they might compete in sports events with disastrous results. Despite their failures, the group remains resilient and continues to face each new challenge with a mix of enthusiasm and cluelessness.

The series also touches on themes of friendship and camaraderie, as the boys often rely on each other to navigate the ups and downs of high school life. While their antics are often self-serving, there are moments where they show genuine concern for one another, highlighting the bonds they share. The humor is often slapstick and situational, with a focus on physical comedy and exaggerated expressions.

Overall, "High School! Kimengumi" is a lighthearted and humorous portrayal of high school life, characterized by its quirky characters and absurd situations. The episodic nature of the series allows for a variety of comedic scenarios, making it a straightforward and entertaining watch for fans of school-based comedies.