"Wotakoi: Love is Hard for Otaku" centers on the lives of four office workers who navigate the complexities of relationships while embracing their otaku identities. The story begins with Narumi Momose, a fujoshi who hides her otaku interests from her coworkers after a past relationship ended due to her hobbies. She reconnects with Hirotaka Nifuji, a childhood friend and fellow otaku, who is aware of her interests and shares similar passions for gaming and manga. The two quickly enter into a romantic relationship, agreeing to date while maintaining their otaku lifestyles. Their dynamic explores the challenges of balancing work, love, and personal interests, often highlighting the humor and misunderstandings that arise from their shared quirks.

Alongside Narumi and Hirotaka, the series introduces two other couples: Hanako Koyanagi and Tarou Kabakura, who are coworkers in a long-term relationship despite their constant bickering, and Naoya Nifuji, Hirotaka’s younger brother, who develops a crush on Koyanagi’s younger sister, Kou. Hanako and Tarou’s relationship provides a contrast to Narumi and Hirotaka’s, showcasing a more mature yet equally comedic dynamic as they navigate their shared otaku interests and workplace interactions. Naoya and Kou’s storyline adds a youthful perspective, focusing on the awkwardness of first love and the challenges of expressing feelings.

The narrative is episodic, with each chapter or episode delving into the characters’ daily lives, blending romantic moments with comedic situations rooted in otaku culture. Themes of acceptance, self-expression, and the intersection of personal and professional lives are explored through the characters’ interactions. The series emphasizes the importance of finding partners who understand and share one’s passions, while also addressing the societal stigma often associated with otaku interests. Through its lighthearted yet relatable storytelling, "Wotakoi" offers a nuanced portrayal of modern relationships and the joys of embracing one’s true self.