"Mobile Suit Gundam-san" is a comedic parody series that reimagines the iconic "Mobile Suit Gundam" franchise with a lighthearted and satirical approach. The series condenses the original 1979 "Mobile Suit Gundam" storyline into short, humorous vignettes, often exaggerating character traits and situations for comedic effect. The narrative retains the core premise of the Universal Century timeline, where Earth Federation forces battle the Principality of Zeon in a war for independence, but the tone is far removed from the serious and dramatic nature of the original.

The main characters from the original series, such as Amuro Ray, Char Aznable, Bright Noa, and Sayla Mass, are reimagined with exaggerated personalities and quirks. Amuro, the young pilot of the RX-78-2 Gundam, is portrayed as a socially awkward and often clueless teenager, while Char, the enigmatic rival, is depicted as overly dramatic and obsessed with his rivalry with Amuro. Bright Noa, the captain of the White Base, is shown as a strict but easily flustered leader, and Sayla Mass is given a more playful and mischievous demeanor. The interactions between these characters are filled with absurd humor, breaking the fourth wall and poking fun at the tropes and conventions of the original series.

The plot loosely follows the events of the original "Mobile Suit Gundam," such as the White Base's journey from Side 7 to Earth, the battles with Zeon forces, and the personal struggles of the crew. However, these events are presented in a highly exaggerated and comedic manner. For example, the Gundam's iconic beam saber is humorously oversized, and the battles often devolve into slapstick comedy. The series also introduces new, absurd scenarios, such as Char attempting to deliver pizza while piloting his Zaku, or Amuro struggling with mundane tasks like laundry while in the middle of a war.

The humor in "Mobile Suit Gundam-san" is heavily reliant on parody and meta-commentary, often referencing the original series' plot points, character dynamics, and even its animation quirks. The series also includes playful nods to the broader Gundam franchise, making it accessible to longtime fans while still entertaining newcomers. Despite its comedic tone, the series maintains a clear respect for the source material, using its parody to highlight the enduring legacy of "Mobile Suit Gundam" while offering a fresh and humorous take on its characters and story.