"Seitokai Yakuindomo*" is a comedy anime series set in Ousai Academy, a formerly all-girls school that has recently become co-ed. The story centers around the student council and its members, who navigate the daily absurdities of school life with a heavy focus on humor, particularly through innuendo and double entendres. The protagonist, Takatoshi Tsuda, is one of the few male students at the school and is reluctantly recruited into the student council as the vice president. His calm and rational demeanor often contrasts with the eccentric personalities of his fellow council members.

The student council president, Shino Amakusa, is a sharp and assertive leader with a penchant for making inappropriate jokes, often at Tsuda's expense. The secretary, Aria Shichijou, is a wealthy and somewhat airheaded girl who frequently misunderstands situations, leading to comedic misunderstandings. The treasurer, Suzu Hagimura, is a genius with a childlike appearance, often using her intellect to contribute to the council's antics. The series also features recurring characters such as Kotomi Tsuda, Takatoshi's younger sister, and Uomi, a quiet and stoic classmate who occasionally joins the council's activities.

The plot is episodic, with each episode presenting a series of loosely connected skits and scenarios. These range from mundane school tasks, such as organizing events or dealing with school regulations, to more absurd situations, like the council members engaging in bizarre competitions or discussing risqué topics. The humor is largely driven by wordplay, situational comedy, and the characters' exaggerated reactions to the often absurd circumstances they find themselves in. Despite the frequent use of sexual humor, the series maintains a lighthearted tone and avoids explicit content, relying instead on innuendo and clever writing.

Throughout the series, the dynamics between the characters evolve, with Tsuda often serving as the straight man to the other council members' antics. The interactions between the characters highlight their distinct personalities and quirks, creating a comedic ensemble that drives the narrative forward. While the series lacks a central overarching plot, its episodic structure allows for a variety of comedic scenarios that showcase the characters' chemistry and the absurdity of their daily lives. The humor and character interactions remain the primary focus, making "Seitokai Yakuindomo*" a straightforward yet entertaining comedy series.