Sango features as a supporting character in "Yashahime: Princess Half-Demon - The Second Act," defined by her family connections and lasting legacy. Married to Miroku, she mothers twin daughters, Kin'u and Gyokuto, and a son, Hisui, born two years after the twins.

After the original series, Sango lives a village life, balancing motherhood with her demon slayer skills. She cares for her children, often carrying the infant Hisui on her back during household tasks, and interacts with Kagome following Kagome's return through the well. Her son Hisui later trains as a demon slayer under Sango's brother, Kohaku, inheriting her signature weapon, the Hiraikotsu, continuing her combat legacy.

Sango attends significant pre-sequel events, such as the birth of Sesshomaru and Rin's twin daughters, Towa and Setsuna, on the night of a lunar eclipse. However, during the forest fire that separated those twins as children, Sango—alongside Miroku, Inuyasha, Kagome, and Shippo—was absent.

Her influence is evident in Hisui's personality and values; he displays seriousness and dedication reminiscent of Sango's traits, showing none of Miroku's lecherous tendencies. Sango's relationships with original characters like Kagome and Kohaku persist, though her direct role in the sequel's main narrative is minimal.