"Plus-Sized Misadventures in Love" centers on Chiyo Ohkawa, a plus-sized woman navigating the complexities of self-acceptance, societal expectations, and romantic relationships. Chiyo works as a designer at a fashion company, where she often feels out of place due to her size and the industry's emphasis on thinness. Despite her insecurities, she is passionate about her work and dreams of creating clothing that celebrates all body types.

The narrative explores Chiyo's interactions with her colleagues, particularly Hiroto Takanashi, a handsome and confident coworker who initially seems indifferent to her. As the story progresses, Hiroto begins to appreciate Chiyo's talent and kindness, leading to a gradual development of mutual respect and affection. Their relationship is marked by moments of misunderstanding and vulnerability, as both characters confront their own biases and fears.

Chiyo's journey is also shaped by her friendships, particularly with her supportive best friend, Yuri, who encourages her to embrace her identity and pursue her goals. The series delves into themes of body positivity, workplace dynamics, and the challenges of finding love while staying true to oneself. Through its portrayal of Chiyo's experiences, the story highlights the importance of self-worth and the impact of societal pressures on personal and professional lives. The characters' growth and interactions drive the narrative, offering a heartfelt exploration of love, acceptance, and resilience.