"Those Snow White Notes" centers on Sawamura Setsu, a talented young shamisen player from Aomori Prefecture, who struggles to find his own musical voice after the death of his grandfather, a renowned shamisen master. Setsu’s grandfather, Umeko, was his mentor and the source of his inspiration, but his passing leaves Setsu feeling lost and disconnected from the instrument he once loved. Despite his exceptional skill, Setsu feels overshadowed by his grandfather’s legacy and grapples with the pressure to live up to his expectations.

The narrative follows Setsu as he moves to Tokyo, seeking a fresh start and a way to rediscover his passion for the shamisen. In the city, he encounters a diverse group of individuals who influence his journey, including Yuna, a cheerful and supportive classmate, and Rai, a mysterious and skilled shamisen player who becomes both a rival and a source of motivation. Through these interactions, Setsu begins to explore new styles and techniques, gradually breaking free from the constraints of tradition and finding his own unique sound.

The series delves into the cultural and emotional significance of the shamisen, portraying it not just as an instrument but as a medium for self-expression and connection. Setsu’s growth is marked by his participation in various performances and competitions, where he confronts his insecurities and learns to channel his emotions into his music. The story also explores themes of family, legacy, and individuality, as Setsu navigates his relationships with his estranged mother, a famous enka singer, and his younger brother, who harbors his own musical aspirations.

As Setsu’s journey unfolds, the series highlights the challenges and rewards of pursuing a passion, emphasizing the importance of perseverance and authenticity. The narrative balances moments of intense musical performance with quieter, introspective scenes, creating a rich tapestry of character development and emotional depth. Through its exploration of the shamisen and its cultural context, "Those Snow White Notes" offers a compelling portrayal of artistic growth and the search for identity.