"The Highschool Life of a Fudanshi" is a comedic slice-of-life anime that explores the daily experiences of Ryo Sakaguchi, a high school boy who identifies as a fudanshi—a male fan of boys' love (BL) content. The series humorously delves into Ryo's passion for BL manga, games, and fantasies, while navigating the challenges of being a minority within the fandom, which is predominantly female. Ryo's interactions with his friends and classmates often highlight the misunderstandings and stereotypes surrounding male BL fans, as well as the camaraderie he shares with fellow enthusiasts.

Ryo's circle of friends includes Yuujirou Shiratori, his childhood friend who is initially unaware of Ryo's fudanshi identity but later becomes supportive; Akira Ueda, a classmate who shares Ryo's interest in BL and often engages in discussions about the genre; and Rumi Nishihara, a fujoshi (female BL fan) who becomes a close confidante and collaborator in Ryo's BL-related endeavors. The group frequently finds themselves in humorous situations, such as attending BL events, debating tropes, or trying to hide their interests from judgmental peers.

The narrative is episodic, with each episode focusing on a specific aspect of Ryo's life as a fudanshi. Themes include the social stigma faced by male BL fans, the dynamics of fandom culture, and the universal struggles of high school life. The series balances lighthearted comedy with moments of genuine reflection on the importance of finding like-minded individuals and embracing one's passions without fear of judgment. Through its relatable and often exaggerated scenarios, "The Highschool Life of a Fudanshi" offers an entertaining glimpse into the world of BL fandom from a unique perspective.