"Angie Girl" centers around Angie Yamanouchi, a high school student who discovers she is the reincarnation of Venus, the Roman goddess of love and beauty. This revelation comes to light when she encounters a mysterious boy named Lute, who claims to be her guardian and protector. Lute explains that Angie’s awakening as Venus has triggered a cosmic conflict, as other reincarnated deities from various mythologies are now vying for power. These deities, known as the "Seven Shadows," seek to eliminate Angie to prevent her from restoring balance to the world.

As Angie grapples with her newfound identity, she must also navigate the complexities of her daily life, including her relationships with friends and family. Her best friend, Maki, becomes a key ally, offering emotional support and grounding her in the human world. Meanwhile, Lute serves as both a guide and a combatant, training Angie to harness her divine powers while protecting her from the Seven Shadows. The series explores themes of destiny, identity, and the tension between mortal and divine responsibilities.

The narrative unfolds through a series of battles and confrontations with the Seven Shadows, each representing a different mythological figure. These encounters force Angie to confront her fears and insecurities, as well as the moral dilemmas of wielding immense power. The story also delves into the backstories of the Seven Shadows, revealing their motivations and the tragic circumstances that led them to oppose Angie. As the conflict escalates, Angie must decide whether to embrace her role as Venus fully or seek a way to reconcile her divine duties with her human desires.

The series balances action-packed sequences with moments of introspection, highlighting Angie’s growth as she learns to accept her dual nature. The interplay between the human and divine realms is a recurring motif, emphasizing the challenges of bridging two vastly different worlds. By the conclusion, Angie’s journey culminates in a climactic showdown that tests her resolve and the strength of her bonds with those around her.