Ishikawa operates as the lead investigator and technology specialist for Public Security Section 9. His core duties encompass covert intelligence gathering, information warfare, and detecting data manipulation. Utilizing advanced hacking skills, he infiltrates computer systems to secure mission-critical intelligence on targets. While indispensable to operational success, he primarily works remotely from an analysis room rather than engaging in fieldwork.

His cybernetic enhancement level is designated low prosthetic percentage, inferred from an extended injury recovery period and substantial biological components. Precise cybernetic specifications remain undisclosed.

Prior to Section 9, Ishikawa served in the military alongside Motoko Kusanagi and Batou. This shared history established his enduring professional bonds with key team members, though his specific military role is not detailed.

During the second season, Ishikawa aids Section 9's refugee crisis and Individual Eleven operations. He participates in the high-stakes decoy transport of nuclear material through refugee zones, involving government agent Kazundo Gouda. Later, on Etorofu Island, he sustains injuries when a Section 9 tiltrotor aircraft explodes during the confrontation with Hideo Kuze.

His involvement extends to the Solid State Society film, where he investigates the Puppeteer case—a probe into mass kidnappings and a government system manipulating abused children and comatose seniors. Throughout these events, his methodology remains anchored in cyber surveillance and information analysis.