"Miss Caretaker of Sunohara-sou" centers around Aki Shiina, a high school boy who moves into Sunohara-sou, a dormitory managed by his aunt, Ayaka Sunohara. The dormitory is exclusively for girls, but Ayaka makes an exception for Aki due to his family circumstances. Aki’s arrival introduces him to the quirky and lively residents of Sunohara-sou, each with distinct personalities and backgrounds.

The narrative unfolds through Aki’s daily interactions with the residents, blending slice-of-life moments with lighthearted comedy. Among the residents is Yuzu Yukimoto, a cheerful and energetic girl who quickly becomes Aki’s closest friend. Nana Takanashi, a reserved and studious girl, often contrasts with Yuzu’s exuberance, creating a dynamic interplay between the characters. Sumire Yamanashi, another resident, is a mature and composed figure who occasionally offers guidance to the group. Rounding out the main cast is Yuri Saegusa, a shy and introverted girl who gradually opens up to Aki and the others.

The series explores themes of friendship, personal growth, and the challenges of adolescence, all set against the backdrop of the communal life at Sunohara-sou. Aki’s presence as the sole male resident leads to humorous and sometimes awkward situations, but his genuine kindness and willingness to help others foster a sense of camaraderie among the group. Ayaka Sunohara, the caretaker, serves as a maternal figure, overseeing the dormitory with a mix of warmth and occasional mischief, adding to the series’ light-hearted tone.

Episodic in structure, the story focuses on the everyday lives of the characters, highlighting their interactions, small adventures, and the bonds they form. The narrative avoids heavy drama, instead emphasizing the charm of ordinary moments and the gradual development of relationships within the dormitory. Through its focus on character dynamics and relatable scenarios, "Miss Caretaker of Sunohara-sou" offers a gentle and entertaining portrayal of youthful life and the connections that define it.