"Tsuyokiss - Cool×Sweet" is a 12-episode anime series based on a visual novel, blending elements of romantic comedy and harem genres. The story centers around Sunao Konoe, a high school student who transfers to Kuro Gane Academy, a prestigious institution known for its rigorous academic standards and competitive environment. Sunao is determined to excel academically and socially, but his life takes an unexpected turn when he becomes entangled with several female classmates, each with distinct personalities and backgrounds.

The narrative unfolds as Sunao navigates his relationships with these girls, who are all part of the school's student council. The primary characters include Leo Tsukigami, the confident and assertive student council president; Natsuki Kurebayashi, a cheerful and energetic girl with a strong sense of justice; Mao Mizusawa, a shy and reserved girl who struggles with self-confidence; and Erika Kurusu, a cool and composed individual with a mysterious demeanor. Each girl represents a different archetype within the harem genre, and their interactions with Sunao drive much of the plot.

As the series progresses, Sunao finds himself in various comedic and romantic situations, often stemming from misunderstandings or the girls' attempts to win his affection. The student council setting provides a framework for these interactions, with school events, competitions, and challenges serving as backdrops for character development and relationship dynamics. The series balances lighthearted humor with moments of emotional depth, particularly as the characters confront their insecurities and aspirations.

The plot does not follow a single overarching storyline but instead focuses on episodic scenarios that highlight the evolving relationships between Sunao and the girls. This structure allows for exploration of each character's personality and backstory, offering glimpses into their motivations and struggles. While the series adheres to many conventions of the harem genre, it also incorporates themes of self-improvement, friendship, and the pursuit of personal goals.

"Tsuyokiss - Cool×Sweet" maintains a straightforward narrative approach, prioritizing character interactions and comedic moments over complex plot developments. The series concludes without a definitive resolution to the romantic entanglements, leaving the relationships open-ended and reflective of the visual novel's branching paths. This approach aligns with the source material's emphasis on player choice and multiple outcomes. Overall, the series provides a lighthearted and entertaining exploration of high school life, romance, and the dynamics of a close-knit group of friends.