"Gakuen Babysitters" centers around Ryuuichi Kashima, a high school student who, along with his younger brother Kotarou, becomes orphaned after their parents die in a plane crash. The siblings are taken in by the chairwoman of Morinomiya Academy, who offers them a place to live on the condition that Ryuuichi helps at the school’s daycare center, which caters to the children of the faculty. The series explores Ryuuichi’s adjustment to his new responsibilities as he balances school life with caring for the toddlers at the daycare, as well as his efforts to provide emotional stability for Kotarou, who is deeply affected by their parents’ death.

The daycare center is populated by a lively group of young children, each with distinct personalities. Ryuuichi quickly forms bonds with the kids, including Taka, a cheerful but mischievous boy; Kirin, a shy and reserved girl; and the twins Kazuma and Kota, who are often seen together. The interactions between Ryuuichi and the children are heartwarming and often humorous, showcasing his patience and nurturing nature. Kotarou, initially withdrawn and quiet, gradually opens up as he interacts with the other children and begins to heal from his grief.

The narrative also delves into the lives of the other characters at Morinomiya Academy, including Ryuuichi’s classmates and the daycare staff. Usaida, the laid-back and enigmatic daycare worker, provides comic relief while occasionally offering sage advice. Ryuuichi’s classmate and friend, Hayato Kamitani, initially comes across as gruff and intimidating but reveals a softer side as he becomes more involved with the daycare. The series balances lighthearted moments with emotional depth, addressing themes of family, loss, and the importance of community support.

Throughout the series, Ryuuichi’s dedication to the children and his brother highlights his resilience and compassion. The story emphasizes the impact of small, everyday acts of kindness and the ways in which people can find strength and healing through connection. The daycare setting serves as a backdrop for exploring the challenges and joys of caregiving, as well as the growth of both the children and the teenagers who look after them.