"Tales of Eternia" is a 26-episode anime series based on the popular "Tales of" RPG franchise, specifically adapting the 2000 game of the same name. The story is set in a world divided between two planets, Inferia and Celestia, which are connected by a mysterious energy source called the Orbus Barrier. The narrative centers on Reid Hershel, a skilled martial artist, and his childhood friend Farah Oersted, who live in the peaceful village of Rasheans on Inferia. Their lives are disrupted when they encounter a Celestian girl named Meredy, who is pursued by a mysterious organization seeking to exploit the Orbus Barrier for destructive purposes.

As Reid, Farah, and Meredy embark on a journey to protect both worlds, they uncover the truth about the Orbus Barrier and its connection to an ancient conflict between Inferia and Celestia. The trio is joined by additional allies, including Keele Zeibel, a young scholar with a deep understanding of the Orbus Barrier, and Chat, a sentient Cheagle (a small, winged creature) who provides comic relief and emotional support. Together, they face numerous challenges, including battles against the malevolent organization Aifread and its enigmatic leader, Shizel, who seeks to destroy the Orbus Barrier to achieve her own ends.

The plot explores themes of coexistence, environmental balance, and the consequences of unchecked ambition. As the group travels across both planets, they encounter diverse cultures, confront moral dilemmas, and gradually piece together the history of the Orbus Barrier. The story builds toward a climactic confrontation with Shizel, whose actions threaten to destabilize the delicate equilibrium between Inferia and Celestia. The series balances action, character development, and world-building, offering a cohesive narrative that stays true to the spirit of the original game while expanding on its lore and emotional depth.