"Virus Buster Serge" is a 12-episode anime series set in a futuristic world where humanity faces a deadly threat from mysterious creatures known as "Lucifer Awakenings." These beings are the result of a catastrophic event caused by the "Lucifer Virus," a bio-engineered pathogen that transforms humans into monstrous entities. The story centers on Serge, a young man who becomes a "Virus Buster," a specialized agent tasked with combating the Lucifer Awakenings and protecting humanity.

Serge is recruited into the Virus Busters organization, a secretive group equipped with advanced technology and weapons designed to neutralize the Lucifer Awakenings. Alongside his partner, the enigmatic and skilled fighter Reiko, Serge undergoes rigorous training and missions to confront the growing threat. The series explores the dynamics of their partnership, as well as the moral and ethical dilemmas posed by the Lucifer Virus and its effects on humanity.

As the story progresses, Serge and Reiko uncover deeper layers of the conspiracy surrounding the Lucifer Virus. They encounter various factions, including rogue scientists, government agencies, and other Virus Busters, each with their own agendas. The narrative delves into themes of identity, survival, and the consequences of unchecked scientific experimentation. The Lucifer Awakenings themselves are portrayed as tragic figures, former humans whose transformations are often involuntary and irreversible.

The series builds toward a climactic confrontation with the origins of the Lucifer Virus, revealing the involvement of powerful entities and the potential for a global catastrophe. Serge and Reiko must navigate a web of betrayal, sacrifice, and difficult choices to prevent the virus from spreading further. The anime balances action-packed sequences with moments of introspection, highlighting the personal struggles of its characters as they grapple with their roles in a world on the brink of collapse.