The anime series "My Mental Choices Are Completely Interfering with My School Romantic Comedy" centers around Kanade Amakusa, a high school student cursed with a peculiar affliction known as the "Absolute Choice." This curse forces him to make random, often absurd decisions presented as two options, which he must act upon immediately. These choices range from trivial matters, such as selecting between two types of bread, to more embarrassing or dangerous scenarios, like stripping in public or jumping off a roof. Failure to comply results in excruciating pain, leaving Kanade no choice but to obey.

Kanade's life takes a dramatic turn when the curse leads him to a pivotal decision: to either transfer to another world or receive a sacred power. Choosing the latter, he gains the ability to summon a mysterious girl named Chocolat, who claims to be a goddess. Chocolat explains that Kanade must complete a series of trials to lift the curse, but her guidance is often cryptic and unhelpful. As Kanade navigates his bizarre predicament, he becomes entangled in a chaotic romantic comedy involving several female classmates.

Among these characters is Yukihira Furano, a sharp-tongued and aloof girl who harbors a secret affection for Kanade. Despite her abrasive demeanor, she frequently finds herself drawn into his absurd situations. Another key figure is Ouka Yuuki, a cheerful and athletic classmate who initially appears as a rival but gradually develops feelings for Kanade. Her straightforward and energetic personality contrasts with Furano's reserved nature, creating a dynamic interplay of emotions and misunderstandings.

The series explores the comedic and often surreal consequences of Kanade's curse, as his forced decisions lead to increasingly ridiculous scenarios. These situations often involve misunderstandings, slapstick humor, and romantic tension, as the characters navigate their relationships amidst the chaos. The narrative balances absurd comedy with moments of genuine emotional development, particularly as Kanade begins to understand the complexities of his relationships with Furano, Ouka, and others.

Throughout the series, the curse serves as both a source of humor and a catalyst for character growth. Kanade's struggles with the Absolute Choice highlight themes of agency, self-determination, and the unpredictability of life. The interactions between the characters reveal their vulnerabilities and aspirations, adding depth to the comedic premise. By the end of the series, Kanade's journey to break the curse culminates in a resolution that ties together the romantic and comedic elements of the story, offering closure to the characters' arcs.