"ViVid Strike!" is a 12-episode anime series set in the "Magical Girl Lyrical Nanoha" universe, focusing on martial arts and personal growth. The story centers on Fuuka Reventon, a young girl living in a foster home who struggles with feelings of abandonment and anger. After a violent altercation with a group of bullies, Fuuka is discovered by Nove Nakajima, a martial arts instructor and former member of the TSAB (Time-Space Administration Bureau). Recognizing Fuuka's potential, Nove offers her a chance to train at her gym, where she begins to learn the martial art style known as "StrikerS."

Fuuka's journey intertwines with that of her childhood friend, Rinne Berlinetta, who was adopted by a wealthy family after they were separated. Rinne has become a skilled martial artist under the guidance of her adoptive sister, Einhart Stratos, a descendant of the legendary warrior Claus G.S. Ingvalt. The reunion between Fuuka and Rinne is initially strained, as Fuuka harbors resentment over Rinne's seemingly perfect life. However, as the two reconnect, they confront their shared past and the emotional scars that have shaped them.

The narrative explores themes of rivalry, forgiveness, and self-discovery as Fuuka and Rinne prepare for a major martial arts tournament. Fuuka's growth as a fighter is paralleled by her emotional development, as she learns to channel her anger into determination and begins to heal from her past. Rinne, meanwhile, grapples with the pressure of living up to expectations and the guilt of leaving Fuuka behind. Their paths converge in the tournament, where they must face not only each other but also powerful opponents, including Einhart and other skilled fighters.

The series features a mix of intense martial arts battles and character-driven drama, with a focus on the relationships between the main characters. Supporting characters, such as Nove, Einhart, and other members of the TSAB, provide additional depth to the story, offering guidance and challenges that shape Fuuka and Rinne's journeys. The anime balances action with emotional moments, culminating in a resolution that emphasizes personal growth and the importance of moving forward.