"Oshiete Hokusai!: The Animation" is a short-form anime series that blends historical elements with comedic and educational storytelling. The narrative revolves around the legendary Japanese ukiyo-e artist Katsushika Hokusai, who is reimagined as a young, eccentric girl living in modern-day Tokyo. Despite her historical fame, this version of Hokusai is depicted as a carefree and somewhat clueless individual, often relying on her apprentice, a young boy named Edo, to navigate the complexities of contemporary life.

The series explores Hokusai's attempts to create art while adapting to modern society, often leading to humorous misunderstandings and mishaps. Each episode is structured around a specific theme or challenge, such as learning about new art techniques, dealing with technology, or interacting with people who are unaware of her historical significance. Edo serves as the straight man to Hokusai's antics, providing explanations and guidance while also being drawn into her unpredictable schemes.

The plot is episodic, with each installment offering a self-contained story that highlights Hokusai's unique perspective on art and life. The series incorporates educational elements, offering insights into traditional Japanese art and culture, particularly ukiyo-e, while maintaining a lighthearted and comedic tone. Historical references are woven into the narrative, often juxtaposed with modern settings and situations to create a blend of past and present.

The main characters include Hokusai, whose boundless enthusiasm and artistic passion drive the story, and Edo, whose grounded personality balances her eccentricity. Supporting characters, such as Hokusai's neighbors and acquaintances, add variety to the episodic structure, often serving as foils or catalysts for the central duo's adventures. The series uses its characters and scenarios to explore themes of creativity, tradition, and the intersection of history with modernity, all while delivering humor and charm in a concise format.