"Live On Cardliver Kakeru" is a 52-episode anime series that blends elements of card gaming, action, and adventure. The story centers around Kakeru, a young boy who becomes a Cardliver, a professional player of the popular card game "Monster Retsuden ORTEGA." In this world, Cardlivers are celebrated figures who duel using holographic monsters summoned from their cards. Kakeru aspires to become the greatest Cardliver, following in the footsteps of his older brother, Shou, who mysteriously disappeared after a high-stakes duel.

Kakeru begins his journey with a deck inherited from Shou, which includes the rare and powerful card "ORTEGA." As he progresses, he encounters a diverse cast of rivals and allies, each with their own motivations and unique decks. Among them is Akira, a skilled and confident Cardliver who becomes both a rival and a friend, and Rui, a mysterious girl with a deep connection to the origins of the game. The series explores Kakeru's growth as a player and his quest to uncover the truth behind his brother's disappearance, which is tied to the enigmatic "ORTEGA" card and its significance in the game's lore.

The narrative is structured around Kakeru's participation in various tournaments and challenges, each designed to test his strategic thinking and adaptability. Along the way, he learns valuable lessons about teamwork, perseverance, and the importance of understanding his opponents. The series also delves into the darker aspects of the Cardliver world, including corporate manipulation, the exploitation of players, and the ethical implications of advanced technology used in the game.

As Kakeru advances, he uncovers a conspiracy involving the creators of "Monster Retsuden ORTEGA," who seek to control the game for their own purposes. The climax of the series revolves around Kakeru's final confrontation with the mastermind behind the conspiracy, where he must use all his skills and the bonds he has formed to protect the integrity of the game and honor his brother's legacy. The story concludes with Kakeru achieving his goal of becoming a top Cardliver while leaving room for future adventures in the ever-evolving world of "Monster Retsuden ORTEGA."