"Genocyber" is a five-episode OVA series set in a dystopian future where advanced biotechnology and cybernetics have become integral to society. The narrative explores themes of corporate greed, human experimentation, and the ethical implications of merging human consciousness with machines. The story is divided into two main arcs, each focusing on different characters and events but connected by the central concept of the Genocyber, a powerful bio-weapon created through the fusion of human psychic abilities and cybernetic enhancements.

The first arc centers on Elaine and Diana, twin sisters with extraordinary psychic powers. Elaine is gentle and empathetic, while Diana is aggressive and unstable. Their abilities attract the attention of the Kuryu Group, a powerful corporation seeking to weaponize psychic potential. The sisters are forcibly separated, with Elaine undergoing experiments to enhance her powers, while Diana is left in a vegetative state after a traumatic incident. The experiments lead to the creation of the Genocyber, a monstrous entity formed when Elaine's consciousness merges with Diana's, resulting in a being of immense destructive power. The Genocyber becomes a symbol of humanity's hubris, as it spirals out of control, wreaking havoc on both the Kuryu Group and innocent civilians.

The second arc shifts focus to a new set of characters, including Melissa, a young girl with latent psychic abilities, and Dr. Alan, a scientist working for the Kuryu Group. Melissa becomes a target for the corporation, which seeks to replicate the Genocyber's power. Dr. Alan, initially complicit in the experiments, begins to question the morality of his work as he witnesses the suffering caused by the Genocyber. The arc delves into the consequences of unchecked technological advancement, as the Genocyber continues to evolve, becoming an even greater threat to humanity. The narrative culminates in a climactic confrontation between the Genocyber and those attempting to control or destroy it, highlighting the futility of trying to harness such uncontrollable power.

Throughout the series, the Genocyber serves as both a literal and metaphorical force, representing the dangers of tampering with the boundaries between human and machine. The characters' struggles reflect broader societal issues, such as the exploitation of the vulnerable and the dehumanizing effects of corporate ambition. The series is marked by its dark tone, graphic violence, and exploration of complex ethical dilemmas, making it a notable entry in the cyberpunk genre.