"Osomatsu-kun: Iyami wa Hitori Kaze no Naka" is a 1988 anime special that serves as a continuation of the classic "Osomatsu-kun" series, which originally aired in the 1960s. The story revolves around the Matsuno sextuplets—Osomatsu, Karamatsu, Choromatsu, Ichimatsu, Jyushimatsu, and Todomatsu—who are mischievous, lazy, and perpetually unemployed young men living in a small town. Their antics often lead to chaotic and humorous situations, with their interactions forming the core of the narrative.

The special focuses on Iyami, a recurring character known for his flamboyant personality, catchphrase "Sheeh!", and his rivalry with the sextuplets. Iyami finds himself in a precarious situation when he becomes the target of a mysterious organization. The plot thickens as Iyami is pursued by shadowy figures, forcing him to navigate a series of absurd and comedic challenges. The Matsuno brothers, though initially indifferent to Iyami's plight, eventually become entangled in the chaos, leading to a blend of slapstick humor and lighthearted adventure.

Throughout the story, the dynamic between the sextuplets and Iyami is central, with their interactions driving much of the humor and conflict. The brothers often mock or exploit Iyami, while he, in turn, schemes to outwit them or gain the upper hand. The narrative maintains a comedic tone, with exaggerated situations and over-the-top character reactions typical of the series' style. The special also features other familiar characters, such as Totoko, the vain and self-absorbed girl who often becomes the object of the brothers' affections, and Chibita, their short-tempered friend who runs a local oden cart.

The plot is episodic in nature, with a series of loosely connected events that highlight the characters' quirks and relationships. While the overarching story involves Iyami's predicament, much of the runtime is dedicated to comedic set pieces and character-driven humor. The special captures the essence of the original series, blending nostalgia with the absurdity and charm that defined the Matsuno brothers' adventures. The narrative concludes with a resolution that ties up the central conflict in a typically whimsical manner, leaving the characters to return to their usual antics.