"Inukami!" is a supernatural comedy anime set in a world where humans coexist with spiritual beings known as inukami, who serve as guardians and partners to skilled practitioners called inukami users. The story centers on Keita Kawahira, a lazy and self-centered young man from a prestigious family of inukami users. Despite his lineage, Keita lacks ambition and often shirks responsibility, much to the disappointment of his family. His life takes a dramatic turn when he encounters Youko, a powerful and mischievous inukami who has been sealed away for centuries due to her uncontrollable nature.

Youko is bound to Keita through a contract, but their partnership is far from harmonious. Youko is fiercely independent, brash, and often manipulative, while Keita is reluctant to embrace his duties as an inukami user. Together, they navigate a series of comedic and supernatural adventures, battling malevolent spirits, solving mysteries, and dealing with the eccentricities of other inukami and their users. The dynamic between Keita and Youko is a central focus, with their constant bickering and contrasting personalities driving much of the humor and conflict.

The series introduces a variety of supporting characters, including other inukami users and their partners, each with unique abilities and quirks. Notable figures include Kaoru Kawahira, Keita's diligent and responsible cousin, and her inukami, Nadeshiko, who contrasts sharply with Youko's wild demeanor. The narrative often explores themes of loyalty, responsibility, and the complexities of human-inukami relationships, blending lighthearted comedy with moments of action and emotional depth.

As the story progresses, Keita and Youko face increasingly dangerous threats, including powerful demons and rival inukami users with sinister intentions. Their bond evolves from one of mutual annoyance to a genuine partnership, though their antics and disagreements remain a consistent source of entertainment. The series balances episodic adventures with an overarching plot, culminating in a climactic confrontation that tests their abilities and resolve.

"Inukami!" combines supernatural elements with slapstick humor, romantic undertones, and action-packed sequences, creating a lively and engaging narrative. The interplay between Keita and Youko, along with the colorful cast of characters, ensures a mix of comedy, drama, and supernatural intrigue throughout the series.