"Is It Wrong to Try to Pick Up Girls in a Dungeon?" is set in the fictional city of Orario, a bustling hub where adventurers form alliances with gods and goddesses to explore a massive underground labyrinth known as the Dungeon. The Dungeon is filled with monsters, treasures, and mysteries, attracting adventurers who seek fame, fortune, and power. The story centers on Bell Cranel, a young and inexperienced adventurer who dreams of becoming a hero. Bell is the sole member of the Hestia Familia, a small group led by the goddess Hestia, who deeply cares for him.

Bell’s journey begins with his struggles as a low-level adventurer, often mocked for his lack of strength and experience. However, his life changes when he encounters Ais Wallenstein, a powerful swordswoman from the Loki Familia, who saves him from a near-death encounter in the Dungeon. Inspired by Ais, Bell resolves to grow stronger and prove himself. His rapid growth, fueled by a unique skill called "Realis Phrase," which accelerates his development based on his feelings of admiration and determination, draws attention from other adventurers and deities.

As Bell progresses, he forms bonds with various characters, including Eina Tulle, his advisor at the Guild; Welf Crozzo, a blacksmith and fellow adventurer; and Liliruca Arde, a former thief who becomes a loyal companion. These relationships shape his journey, as he navigates the challenges of the Dungeon and the complex dynamics between the different Familias. The series explores themes of perseverance, camaraderie, and the pursuit of dreams, set against the backdrop of a world where gods and mortals coexist.

The narrative also delves into the political and social structures of Orario, where Familias compete for influence and resources. Hestia’s Familia, though small, becomes a focal point as Bell’s achievements attract both allies and rivals. The series balances action, character development, and world-building, with arcs that highlight Bell’s growth, the mysteries of the Dungeon, and the motivations of those around him. Through his trials and triumphs, Bell gradually evolves from a naive novice into a capable adventurer, earning the respect of his peers and the affection of those who support him.