"Dororo" is a dark fantasy anime set in Japan's Sengoku period, blending historical elements with supernatural themes. The narrative centers on Hyakkimaru, a young man born without limbs, skin, eyes, ears, or a voice due to a pact his father, the ambitious warlord Daigo Kagemitsu, made with 48 demons. In exchange for power and prosperity for his land, Daigo sacrificed his unborn son's body parts to the demons. Hyakkimaru is abandoned and left to die but is rescued by a kind prosthetics maker, Dr. Jukai, who crafts him artificial limbs and trains him to survive.

As Hyakkimaru grows, he discovers he can sense demons and regain his lost body parts by defeating them. Armed with blades hidden in his prosthetic arms and guided by an otherworldly sense of the demons' presence, he embarks on a journey to reclaim his humanity. Along the way, he encounters Dororo, a resourceful and street-smart orphan thief who becomes his companion. Dororo, initially seeking to exploit Hyakkimaru's abilities for personal gain, gradually forms a genuine bond with him, providing emotional support and a human connection that contrasts with Hyakkimaru's solitary existence.

The series explores themes of identity, morality, and the cost of ambition as Hyakkimaru confronts the demons and the consequences of his father's actions. Each demon he defeats restores a part of his body, but the process is fraught with danger and moral ambiguity, as many demons are tied to the suffering of innocent people. The narrative also delves into Dororo's backstory, revealing their own struggles and the impact of war and greed on their life.

As the story progresses, Hyakkimaru's quest brings him into conflict with his father and the broader societal structures that perpetuate suffering. The series balances action-packed battles with introspective moments, examining the human condition and the resilience of the spirit. The dynamic between Hyakkimaru and Dororo evolves from one of mutual convenience to a deep, familial bond, underscoring the importance of connection and compassion in a harsh world. The anime concludes with a resolution that ties together the characters' arcs while leaving room for reflection on the themes of sacrifice, redemption, and the pursuit of humanity.