"Tayutama - Kiss on My Deity" is a 12-episode anime series based on a visual novel by Lump of Sugar. The story is set in the fictional town of Yuuhi, which is known for its deep connection to ancient deities and spiritual traditions. The protagonist, Yūichi Tate, is a high school student whose family has long served as guardians of the town's sacred shrine. Yūichi's life takes a dramatic turn when he accidentally awakens a powerful deity named Mashiro, who has been sealed within the shrine for centuries.

Mashiro, a Tayutayu—a race of divine beings worshipped as gods—emerges with a playful and somewhat naive personality, but her presence disrupts the balance of the town's spiritual energy. As a result, other Tayutayu begin to appear, each with their own agendas and powers. Yūichi is tasked with protecting Mashiro and maintaining harmony between the human world and the divine realm, a responsibility that grows increasingly complex as rival deities and supernatural threats arise.

The narrative explores themes of coexistence between humans and deities, as well as the challenges of balancing personal desires with duty. Yūichi's relationships with Mashiro and other key characters, such as his childhood friend Kanae and the mysterious deity Seria, drive much of the story. These relationships are tested as the characters navigate conflicts involving ancient rituals, forgotten histories, and the consequences of tampering with divine power.

The plot is structured around episodic encounters with various Tayutayu, each of whom brings new challenges and revelations about the town's spiritual heritage. As the story progresses, Yūichi and Mashiro grow closer, and their bond becomes central to resolving the overarching conflict. The series blends elements of romance, fantasy, and action, with a focus on character development and the interplay between human emotions and divine intervention.

The anime maintains a balance between lighthearted moments and more serious, dramatic sequences, reflecting the dual nature of its themes. By the conclusion, the story resolves the immediate threats to Yuuhi while leaving room for contemplation about the enduring relationship between humans and the divine. The series is characterized by its exploration of mythology, its ensemble cast of deities, and its emphasis on the protagonist's journey of self-discovery and responsibility.